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G1513

Sigma-Aldrich

Glycerol formal

47-67% 5-hydroxy-1,3-dioxane basis (GC), 33-53% 4-hydroxymethyl-1,3-dioxolane basis (GC)

Empirical Formula (Hill Notation):
C4H8O3
CAS Number:
Molecular Weight:
104.10
Beilstein:
103206
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

assay

33-53% 4-hydroxymethyl-1,3-dioxolane basis (GC)
47-67% 5-hydroxy-1,3-dioxane basis (GC)

contains

~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer

refractive index

n20/D 1.451 (lit.)

bp

192-193 °C (lit.)

density

1.203 g/mL at 25 °C (lit.)

SMILES string

OCC1COCO1.OC2COCOC2

InChI

1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2

InChI key

JIUMSISXCKWZTA-UHFFFAOYSA-N

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General description

Glycerol formal (GlyF) includes isomers, namely, 4-hydroxymethyl-1,3-dioxolane and 5-hydroxy-1,3-dioxane. It is a glycerol synthon with a combination of two 5- and 6-membered ring isomers.

Application

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

Packaging

1 L in glass bottle
100, 250 mL in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

199.4 °F - closed cup

Flash Point(C)

93 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

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Properties of fatty acid glycerol formal ester (FAGE) for use as a component in blends for diesel engines
Lapuerta M, et al.
Biomass and Bioenergy, 130-140 (2015)
Selective catalytic etherification of glycerol formal and solketal with dialkyl carbonates and K 2 CO 3
Selva M, et al.
Green Chemistry, 188-200 (2012)
Sarah Nickolls et al.
Advances in pharmacological sciences, 2011, 608912-608912 (2011-12-14)
GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. However, this approach is prone to a range
Kazuo Hotta et al.
Anticancer research, 35(9), 4681-4689 (2015-08-09)
We investigated whether hepatic multidrug resistance-associated protein 2 (ABCC2) is involved in the hepatobiliary excretion of regorafenib, a novel multi-kinase inhibitor, using Sprague-Dawley (SD) rats and Eisai hyperbilirubinemic rats (EHBR) lacking the efflux transporter ABCC2. The involvement of organic anion-transporting

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