G5668

Sigma-Aldrich

GW1929 hydrate

>98% (HPLC), solid

Synonym(s):
N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate
Empirical Formula (Hill Notation):
C30H29N3O4 · xH2O
Molecular Weight:
495.57 (anhydrous basis)
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

assay

>98% (HPLC)

form

solid

solubility

DMSO: 20 mg/mL

originator

GlaxoSmithKline

SMILES string

[H]O[H].CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c3ccccc3)C(O)=O)cc1)c4ccccn4

InChI

1S/C30H29N3O4.H2O/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23;/h2-18,27,32H,19-21H2,1H3,(H,35,36);1H2/t27-;/m0./s1

InChI key

XSITZVFUXCLFMK-YCBFMBTMSA-N

Gene Information

human ... PPARG(5468)

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

GW1929 is a high affinity agonist of PPAR-γ.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes only, pursuant to an agreement with Glaxo­Smith­Kline

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Secreted Factors from Adipose Tissue Reprogram Tumor Lipid Metabolism and Induce Motility by Modulating PPAR?/ANGPTL4 and FAK.
Blucher, et al.
Molecular Cancer Research, 18, 1849-1862 (2021)

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