G7772

Sigma-Aldrich

D-Glucose 6-phosphate solution

~1 M in H2O (approx. 260 mg per ml)

Synonym(s):
D(+)-Glucopyranose 6-phosphate, Robison ester
Empirical Formula (Hill Notation):
C6H13O9P
CAS Number:
Molecular Weight:
260.14
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

biological source

synthetic (inorganic)

assay

≥99% (TLC)

form

liquid

concentration

~1 M in H2O (approx. 260 mg per ml)

application(s)

thin layer chromatography (TLC): suitable

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC(COP(O)(O)=O)C(O)C(O)C(O)C=O

InChI

1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h1,3-6,8-11H,2H2,(H2,12,13,14)

InChI key

VFRROHXSMXFLSN-UHFFFAOYSA-N

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Biochem/physiol Actions

D-Glucose 6-phosphate binds and inhibits the activity of sarcoendoplasmic reticulum calcium ATPase in rat brains resulting in a decrease in the accumulation of calcium in the endoplasmic reticulum.

Linkage

Prepared from G 7879.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

hazcat

Skin Corr. 1B

storage_class_code

8B - Non-combustible, corrosive hazardous materials

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Glucose-6-phosphate reduces calcium accumulation in rat brain endoplasmic reticulum.
Cole, JT.
Frontiers in Neuroscience, 5, 51-51 (2012)
Fook-Choe Cheah et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(7), 3205-3210 (2014-03-19)
Erythrocytes require glucose-6-phosphate dehydrogenase (G6PD) to generate NADPH and protect themselves against hemolytic anemia induced by oxidative stress. Peroxiredoxin 2 (Prx2) is a major antioxidant enzyme that requires NADPH to recycle its oxidized (disulfide-bonded) form. Our aims were to determine...
Tiffany R Bonnett et al.
Insect biochemistry and molecular biology, 42(12), 890-901 (2012-09-18)
Mountain pine beetles, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae), are native to western North America, but have recently begun to expand their range across the Canadian Rocky Mountains. The requirement for larvae to withstand extremely cold winter temperatures and potentially toxic...
Richard G Conway et al.
PloS one, 7(11), e50349-e50349 (2012-12-05)
(18)F-Fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging of atherosclerosis in the clinic is based on preferential accumulation of radioactive glucose analog in atherosclerotic plaques. FDG-PET is challenging in mouse models due to limited resolution and high cost. We aimed to quantify...
Stephen M Ansell et al.
Mayo Clinic proceedings, 87(6), 571-580 (2012-06-09)
The use of sensitive and specific imaging techniques for accurate initial staging and evaluation of response to therapy in patients with lymphoma is essential for their optimal management. Fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) integrated with computed tomography...

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