Hepatocyte Growth Factor human

HGF, recombinant, expressed in Baculovirus infected High-5 cells, suitable for cell culture

HGF, Hepatopoietin A, Scatter Factor
EC Number:
MDL number:
Pricing and availability is not currently available.

Quality Level

biological source



expressed in Baculovirus infected High-5 cells


>95% (SDS-PAGE)


lyophilized powder


20-40 ng/mL


endotoxin tested

mol wt

~80 kDa


pkg of 5x5 μg
pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles


cell culture | mammalian: suitable


<1.0 EU/μg

UniProt accession no.

storage temp.


Gene Information

human ... HGF(3082)

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Biochem/physiol Actions

Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of cell types including endothelial and epithelial cells, melanocytes, and keratinocytes. It also mediates epithelial morphogenesis. HGF is the ligand for the tyrosine kinase receptor encoded by the met proto-oncogene.

Other Notes

The NSO-expressed recombinant HGF is greater than 95% heterodimeric HGF. The insect cell line-expressed recombinant HGF is a mixture of single chain HGF (predominant) with some heterodimeric HGF. Single chain HGF and heterodimeric HGF are equally active in in vitro assays.

Physical form

Lyophilized from a 0.2 μm filtered solution in 20 mM NaH2PO4 and 500 mM NaCl, pH 7.0 with 50 μg BSA per 1 μg HGF

Preparation Note

Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. After reconstitution, this solution can be stored at 2-8 °C for up to one month or at -20 °C to -70 °C for up to three months. Us a manual defrost freezer and avoid repeated freeze-thaw cycles.

Analysis Note

The biological activity is measured by its ability to induce IL-11 secretion by Saos-2 human osieosarcoma cells.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes


Risk Statement


Safety Statement



NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Masaki Kobayashi et al.
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Ryuichi Tatsumi et al.
American journal of physiology. Cell physiology, 297(2), C238-C252 (2009-06-12)
Regenerative coordination and remodeling of the intramuscular motoneuron network and neuromuscular connections are critical for restoring skeletal muscle function and physiological properties. The regulatory mechanisms of such coordination remain unclear, although both attractive and repulsive axon guidance molecules may be...
R A Furlong
BioEssays : news and reviews in molecular, cellular and developmental biology, 14(9), 613-617 (1992-09-01)
Hepatocyte growth factor, a potent mitogen for epithelial and other cell types, and scatter factor, a stimulant of epithelial cell motility are identical. In addition to these mitogenic and motogenic functions, the factor has been shown to be an epithelial...
Yingjie Liu et al.
Development (Cambridge, England), 136(5), 843-853 (2009-01-30)
Integrin receptors for the extracellular matrix and receptor tyrosine kinase growth factor receptors represent two of the major families of receptors that transduce into cells information about the surrounding environment. Wnt proteins are a major family of signaling molecules that...
Tumay Basar et al.
Infection and immunity, 73(4), 2061-2074 (2005-03-24)
The bacterial pathogen Listeria monocytogenes causes food-borne illnesses leading to gastroenteritis, meningitis, or abortion. Listeria induces its internalization into some mammalian cells through interaction of the bacterial surface protein InlB with host Met receptor tyrosine kinase. Binding of InlB leads...
Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of other cells, including endothelial and epithelial cells, melanocytes, and keratinocytes.
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