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H3128

Sigma-Aldrich

Calconcarboxylic acid

Synonym(s):
3-Hydroxy-4-(2-hydroxy-4-sulfo-1-naphthylazo)naphthalene-2-carboxylic acid, Patton and Reeder’s reagent, 2-Hydroxy-1-(2-hydroxy-4-sulfo-1-naphthylazo)-3-naphthoic acid
Empirical Formula (Hill Notation):
C21H14N2O7S
CAS Number:
Molecular Weight:
438.41
Beilstein:
727492
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

form

powder

Quality Level

mp

300 °C

solubility

1 M NaOH: 10 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

OC(=O)c1cc2ccccc2c(N=Nc3c(O)cc(c4ccccc34)S(O)(=O)=O)c1O

InChI

1S/C21H14N2O7S/c24-16-10-17(31(28,29)30)13-7-3-4-8-14(13)18(16)22-23-19-12-6-2-1-5-11(12)9-15(20(19)25)21(26)27/h1-10,24-25H,(H,26,27)(H,28,29,30)/b23-22-

InChI key

MVQBFZXBLLMXGS-FCQUAONHSA-N

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General description

Calconcarboxylic acid is a useful indicator for calcium titrations with EDTA in the presence of magnesium. It is also required for the staining of proteins in gels.
Calconcarboxylic acid is also known as Patton-Reeder indicator and is used in the determination of calcium at pH 12. Calconcarboxylic acid is a chelating agent and is used in the preparation of chelating sorbent along with chemically modified silica LiChroprep-NH2, for trace metal analysis. Calconcarboxylic acid coupled with 3-aminopropyltriethoxysilane (APS-CCA), a fluorescent probe, facilitates the medical detection of Ca2+ ions in the blood with minimal blood backgrounds using hydrophobic hexadecyltrimethoxysilane (HDS) as substrate in fluorimetric microarray method.

Application

Calconcarboxylic acid (CCA) has been used in the preparation of poly-CCA film for leukemia diagnosis by immobilization, hybridization of DNA and detection by methylene blue and differential pulse voltammetry.

Packaging

5, 25, 100 g in glass bottle

Quality

Contains an inert diluent.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Separation Methods In Proteomics (2005)
An electrochemical biosensor for detection of PML/RARA fusion gene using capture probe covalently immobilized onto poly-calcon carboxylic acid modified glassy carbon electrode
Wei N, et al.
Talanta, 78(4-5), 1227-1234 (2009)
A high-throughput fluorimetric microarray with enhanced fluorescence and suppressed ?coffee-ring? effects for the detection of calcium ions in blood
Ding Y, et al.
Scientific Reports, 6, 38602-38602 (2016)
Javier Villela-Castrejón et al.
Journal of food science, 82(7), 1726-1734 (2017-06-10)
Corn lime cooking generates a large amount of wastewater known as nejayote that is composed of suspended solids and solubilized phytochemicals. Spray drying can be an alternative to recover bioactive molecules, such as ferulic acid, from nejayote. Besides the yield
Li N, Hefferren JJ and Li K
Quantitative Chemical Analysis (2013)

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