All Photos(2)

H5270

Sigma-Aldrich

Hydrocortisone 17-butyrate

Synonym(s):
Cortisol 17-butyrate, 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate
Empirical Formula (Hill Notation):
C25H36O6
CAS Number:
Molecular Weight:
432.55
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

form

solid

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(OC(=O)CCC)C(=O)CO

InChI

1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1

InChI key

BMCQMVFGOVHVNG-TUFAYURCSA-N

Gene Information

human ... NR3C1(2908)

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Application

Hydrocortisone 17-butyrate may be used:
  • in the synthesis of hydrocortisone butyrate (HB)-loaded poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles
  • as a topical corticosteroid (CS) to study its effects on keratinocyte proliferation in hyperproliferant keratinocytes (HaCaT) model
  • in the preparation of solid lipid nanoparticles (SLN)

Packaging

1 g in poly bottle

Biochem/physiol Actions

Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Joseph F Fowler et al.
Cutis, 75(2), 125-131 (2005-03-19)
This multicenter, randomized, double-blind clinical trial involving 89 subjects (86 with chronic hand dermatitis and 3 with atopic dermatitis) compared the safety, efficacy, and cosmetic acceptability of 4 medium-potency topical corticosteroid products: hydrocortisone butyrate (HB) 0.1% cream (Locoid Lipocream), fluticasone
Annesofie Faurschou et al.
Archives of dermatology, 144(5), 620-624 (2008-05-21)
To examine the effect of topical corticosteroid treatment on acute sunburn. Randomized, double-blind clinical trial. University dermatology department. Twenty healthy volunteers with Fitzpatrick skin types I (highly sensitive, always burns easily, tans minimally) through III (sun-sensitive skin, sometimes burns, slowly
Mari Paz Castanedo-Tardan et al.
Pediatric dermatology, 26(6), 739-743 (2010-03-05)
Upon ingestion, the artificial sweetener, aspartame is metabolized to formaldehyde in the body and has been reportedly associated with systemic contact dermatitis in patients exquisitely sensitive to formaldehyde. We present a case of a 9-year-old Caucasian boy with a history
Hidemi Nakagawa
Clinical drug investigation, 26(5), 235-246 (2006-12-14)
Tacrolimus (FK506) ointment is widely used in the treatment of patients with atopic dermatitis. The drug exerts its action by down-regulating antigen-specific T-cell activities and associated proinflammatory cytokine production. A number of clinical studies have evaluated the efficacy and safety
M Kawashima et al.
The British journal of dermatology, 148(6), 1212-1221 (2003-06-28)
Fexofenadine, a nonsedating, H1-receptor selective antihistamine, exhibits consistent efficacy and safety in the treatment of allergic rhinitis and urticaria. The pruritus associated with atopic dermatitis is considered to be induced, in part, by histamine. Therefore, we thought that fexofenadine may

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