All Photos(1)

I139

Sigma-Aldrich

(S)-(−)-IBZM

oil

Synonym(s):
(S)-(−)-3-Iodo-2-hydroxy-6-methoxy-N[(1-ethyl-2-pyrrolidinyl)methyl]benzamide, Iodobenzamide
Empirical Formula (Hill Notation):
C15H21IN2O3
CAS Number:
Molecular Weight:
404.24
MDL number:

form

oil

optical activity

[α]22/D −68.5°, c = 0.63 in methylene chloride(lit.)

color

dark yellow

solubility

H2O: slightly soluble <0.5 mg/mL
DMSO: 49.3 mg/mL
ethanol: 8 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

D2 dopamine receptor antagonist.

Caution

Hygroscopic, photosensitive

Certificate of Analysis

Certificate of Origin

M Cordes et al.
European journal of radiology, 12(3), 182-186 (1991-05-01)
[123I]IBZM is a new radioactive labelled ligand which has a high affinity and specificity to D2-dopamine receptors. The in vivo kinetics of [123I]IBZM were studied in patients with unilateral and bilateral accentuated idiopathic Parkinson's disease. The uptake in the basal
R B Innis et al.
Synapse (New York, N.Y.), 10(3), 177-184 (1992-03-01)
We used the reversibly binding D2 dopamine receptor radioligand [123I]IBZM (iodobenzamide) to test whether the endogenous neurotransmitter dopamine competes in vivo for radiotracer binding measured with single photon emission computed tomography (SPECT). In a series of nonhuman primate experiments (n
M Ichise et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 34(8), 1274-1281 (1993-08-01)
Huntington's disease (HD) is pathologically characterized by neuronal loss and neuroreceptor alterations in the striatum, including a reduction in dopamine receptor density. We evaluated the clinical usefulness of 123I-iodobenzamide (IBZM) D2 receptor SPECT imaging and 99mTc-hexamethylpropyleneamineoxime (HMPAO) brain perfusion SPECT

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