I148

Sigma-Aldrich

Imperatoxin A

>88%, lyophilized powder

Synonym(s):
Ip Txa
Empirical Formula (Hill Notation):
C148H260N58O45S6
CAS Number:
Molecular Weight:
3764.40
MDL number:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

assay

>88%

form

lyophilized powder

storage temp.

−20°C

Amino Acid Sequence

Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Arg-Cys-Lys-Ala-Asp-Asn-Asp-Cys-Cys-Gly-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ala-Glu-Lys-Arg-Cys-Arg

Biochem/physiol Actions

Selective skeletal-type ryanodine sensitive intracellular Ca2+ channel activator found in the scorpion Pandinus

Features and Benefits

This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
F Z Zamudio et al.
FEBS letters, 405(3), 385-389 (1997-04-01)
We present the complete amino acid sequence of Imperatoxin A (IpTx(a)), a 33-amino-acid peptide from the venom of the scorpion P. imperator which activates Ca2+ release channels/ryanodine receptors (RyR) of sarcoplasmic reticulum (SR). The amino acid sequence of IpTx(a) shows...
H H Valdivia et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(24), 12185-12189 (1992-12-15)
We report the purification of two peptides, called "imperatoxin inhibitor" and "imperatoxin activator," from the venom of the scorpion Pandinus imperator targeted against ryanodine receptor Ca(2+)-release channels. Imperatoxin inhibitor has a M(r) of approximately 10,500, inhibits [3H]ryanodine binding to skeletal...
R el-Hayek et al.
The Journal of biological chemistry, 270(48), 28696-28704 (1995-12-01)
We have used [3H]ryanodine binding experiments and single channel recordings to provide convergent descriptions of the effect of imperatoxin A (IpTxa), a approximately 5-kDa peptide from the venom of the scorpion Pandinus imperator (Valdivia, H. H., Kirby, M. S., Lederer...

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