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I1521

Sigma-Aldrich

DES (1-6) IGF II

lyophilized powder, recombinant, expressed in E. coli, suitable for cell culture

CAS Number:
MDL number:
NACRES:
NA.77

biological source

human

Quality Level

recombinant

expressed in E. coli

assay

≥95% (HPLC)

form

lyophilized powder

potency

≤100 ng/mL ED50

mol wt

6,765 Da

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... IGF2(3481)

General description

DES (1-6) IGF-II is a 61 amino acid analog of human insulin-like growth factor II, lacking the first six N-terminal amimo acids. DES (1-6) IGF-II exhibits reduced affinity for IGF binding proteins (IGFBPs), which are known to inhibit the actions of IGF′s.

Application

Used for studies of IGF-II function in cell culture applications. Use in combination with IGF-I, insulin and other forms of IGF-II to study receptor functions and cell signaling.

Other Notes

Recombinant analog of insulin-like growth factor II.

Preparation Note

Prepared from 0.1 M acetic acid.
Synthesized recombinantly in E. coli using a patented fusion protein expression system, DES (1-6) IGF-II is then purified by liquid chromatography. DES (1-6) IGF-II has been developed as an inexpensive, high quality potent analog of IGF-II for use as a growth factor supplement in cell culture. DES (1-6) IGF-II is supplied as a powder, lyophilized from 0.1 M acetic acid. Molecular weight is 6,765 daltons.

Certificate of Analysis

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Certificate of Origin

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