I1759

Sigma-Aldrich

Isosorbide dinitrate

powder

Synonym(s):
ISDN
Empirical Formula (Hill Notation):
C6H8N2O8
CAS Number:
Molecular Weight:
236.14
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

form

powder

contains

~60% lactose

color

white

solubility

organic solvents: soluble (alcohol, acetone and ether)

SMILES string

HC@@1(C@@(H)(ON+(O-)=O)CO2)C@@2(H)C@(H)(ON+(O-)=O)CO1

InChI

1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2

InChI key

MOYKHGMNXAOIAT-UHFFFAOYSA-N

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Biochem/physiol Actions

Nitric oxide (NO) donor and nitrovasodilator. Induces stimulation of corpus mucin biosynthesis in vivo. Used to study the role of nitric oxide in the control of cell growth.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xn

Risk Statement

5-22

RIDADR

UN 2907 4.1 / PGII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Benjamin Medalion et al.
The Journal of thoracic and cardiovascular surgery, 150(3), 607-612 (2015-07-21)
Bilateral internal thoracic artery grafting in elderly patients is controversial. We compared the outcome of bilateral internal thoracic artery grafting with that of single internal thoracic artery and saphenous vein and radial artery conduits in these patients. Patients aged 70 years...
S Fujii et al.
The American journal of physiology, 274(5 Pt 1), G857-G862 (1998-06-05)
Recently, in vivo electron paramagnetic resonance (EPR) spectroscopy and imaging have been widely used to investigate free radical distribution and metabolism in tissues, organs, and whole body of small animals. Endogenous nitric oxide (NO) is an attractive target of this...
Hydralazine and isosorbide dinitrate in heart failure: historical perspective, mechanisms, and future directions.
Robert T Cole et al.
Circulation, 123(21), 2414-2422 (2011-06-03)
Olivier Muller et al.
Circulation. Cardiovascular interventions, 5(6), 791-796 (2012-12-06)
To quantify the changes in arterial dimensions after the acute changes in pressure associated with percutaneous coronary intervention (PCI). Forty-eight patients with one angiographically moderate-to-severe stenosis were included in the study. The pressure proximal and distal to the stenosis and...
Lidong Na et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 301-306 (2012-11-20)
The purpose of this paper is to study the potential of N-succinyl chitosan as a novel permeation enhancer for the intranasal absorption of isosorbide dinitrate (ISDN). A series of N-succinyl chitosan (NSCS) with different degree of succinylation (DS) and molecular...

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