Acridine Mutagen ICR 191

6-Chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride
Empirical Formula (Hill Notation):
C19H21Cl2N3O · 2HCl
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


DMSO: soluble


suitable for Ames test in Salmonella and E. coli (Frameshift mutagenic standard)

storage temp.


SMILES string




InChI key


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Skull and crossbonesHealth hazard

Signal Word


Hazard Statements


Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B


6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

R McKendry et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11455-11459 (1991-12-15)
2fTGH is a human cell line containing the selectable marker guanine phosphoribosyltransferase regulated by alpha interferon (IFN-alpha). Two IFN-alpha-unresponsive mutants were isolated previously at a low frequency (ca. 10(-8)) by selecting mutagenized 2fTGH cells in selective medium containing 6-thioguanine and...
N F Cariello et al.
Mutation research, 414(1-3), 95-105 (1998-06-19)
We report the first use of green fluorescent protein (GFP) for mutation detection. We have constructed a plasmid-based bacterial system whereby mutated cells fluoresce and non-mutated cells do not fluoresce. Fluorescence is monitored using a simple hand-help UV lamp; no...
M Watanabe et al.
Mutation research, 314(1), 27-37 (1994-01-01)
The specificity of frameshift mutations induced by several classes of chemical mutagens was determined using a collection of mutant E. coli lacZ genes. This collection can detect each of five kinds of specific frameshift events by scoring Lac+ revertant colonies....
S A Taft et al.
Environmental and molecular mutagenesis, 23(2), 96-100 (1994-01-01)
Human TK6 lymphoblasts were treated with the acridine derivative ICR-191, and mutants at the hprt locus were isolated. Mutant hprt cDNA was reverse-transcribed from mRNA, amplified by polymerase chain reaction (PCR), and sequenced. Additions of single G:C base pairs (+1...
Katerina Vlasakova et al.
Mutation research, 578(1-2), 225-237 (2005-09-07)
A novel forward mutation assay has been developed in Salmonella typhimurium based on resistance to 5-fluorouracil (FU). The mutational target in the FU assay was determined to be the uracil phosphoribosyl transferase (upp) gene. To validate the upp gene as...

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