Documents

I8768

Sigma-Aldrich

L-N5-(1-Iminoethyl)ornithine hydrochloride

nitric oxide synthase inhibitor

Synonym(s):
L-NIO hydrochloride, L-Ornithine ψ-acetamidine hydrochloride
Empirical Formula (Hill Notation):
C7H15N3O2 · HCl
CAS Number:
Molecular Weight:
209.67
MDL number:
Pricing and availability is not currently available.

SMILES string

CC(NCCCC@H(N)C(O)=O)=N.HCl

InChI

1S/C7H15N3O2.ClH/c1-5(8)10-4-2-3-6(9)7(11)12;/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12);1H/t6-;/m0./s1

InChI key

JIBZSGQTCBWUKL-RGMNGODLSA-N

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

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Biochem/physiol Actions

A potent irreversible inhibitor of nitric oxide synthase.

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-36

WGK Germany

3

Certificate of Analysis
Certificate of Origin
T B McCall et al.
British journal of pharmacology, 102(1), 234-238 (1991-01-01)
1. The synthesis of nitric oxide (NO) from L-arginine by rat peritoneal neutrophils (PMN) and the murine macrophage cell-line J774 and the inhibition of this synthesis by N-iminoethyl-L-ornithine (L-NIO), NG-monomethyl-L-arginine (L-NMMA), NG-nitro-L-arginine (L-NNA) and its methyl ester (L-NAME) were investigated....

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