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K1250

Sigma-Aldrich

6-Ketocholestanol

Synonym(s):
3β-Hydroxy-5α-cholestan-6-one, 5α-Cholestan-3β-ol-6-one
Empirical Formula (Hill Notation):
C27H46O2
CAS Number:
Molecular Weight:
402.65
EC Number:
MDL number:
PubChem Substance ID:

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC(=O)[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-20-16-25(29)24-15-19(28)11-13-27(24,5)23(20)12-14-26(21,22)4/h17-24,28H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,24-,26-,27-/m1/s1

InChI key

JQMQKOQOLPGBBE-ZNCJEFCDSA-N

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Certificate of Analysis

Certificate of Origin

Barbara G Auner et al.
International journal of pharmaceutics, 294(1-2), 149-155 (2005-04-09)
Phloretin and 6-ketocholestanol are penetration enhancers for percutaneous delivery of certain topically applied drugs. In the present study some physicochemical experiments have been performed to elucidate the mechanism of action of phloretin and 6-ketocholestanol. The penetration enhancing effect of phloretin
Vasyl V Shynkar et al.
Biochimica et biophysica acta, 1712(2), 128-136 (2005-06-01)
The dipole potential (Psi(d)) constitutes a large and functionally important part of the electrostatic potential of cell plasma membranes. However, its direct measurement is not possible. Herein, new 3-hydroxyflavone fluorescent probes were developed that respond strongly to Psi(d) changes by
B G Auner et al.
International journal of pharmaceutics, 255(1-2), 109-116 (2003-04-04)
In this study, the effect of lipophilic counter-ions on the permeation of 5-aminolevulinic acid (ALA) in combination with skin impregnation by phloretin and 6-ketocholestanol was evaluated. Standard in vitro permeation experiments with porcine skin were performed analysing the ALA content
C Valenta et al.
International journal of pharmaceutics, 217(1-2), 79-86 (2001-04-09)
In this study the effect of phloretin (PH) and 6-ketocholestanol (KC) on the permeation of progesterone through porcine skin has been examined. Both PH and KC were incorporated into unilamellar L-alpha-phosphatidylcholine (PC) liposomes at different concentrations (7.5, 15, 30 and
J I Alakoskela et al.
Biophysical journal, 80(1), 294-304 (2001-02-13)
Nitro-2,1,3-benzoxadiazol-4-yl (NBD) group is a widely used, environment-sensitive fluorescent probe. The negatively charged dithionite rapidly reduces the accessible NBD-labeled lipids in liposomes to their corresponding nonfluorescent derivatives. In this study both the phospholipid headgroup and acyl chain NBD-labeled L-alpha-1,2-dipalmitoyl-sn-glycero-3-phospho-[N-(4-nitrobenz-2-oxa-1,3-diazole)-ethanolamine] (DPPN)

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