L9650

Sigma-Aldrich

Lithium chloride

for molecular biology, ≥99%

Linear Formula:
LiCl
CAS Number:
Molecular Weight:
42.39
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.31
Pricing and availability is not currently available.

Quality Level

grade

for molecular biology

assay

≥99%

form

powder

mp

605 °C (lit.)

solubility

H2O: 100 mg/mL at 20 °C, clear, colorless

anion traces

sulfate (SO42-): ≤0.01%

cation traces

Ba: ≤0.003%
Fe: ≤0.001%
K: ≤0.01%
Na: ≤0.20%
heavy metals (as Pb): ≤0.002%

foreign activity

DNase, NICKase, RNase, protease, none detected

SMILES string

[Li+].[Cl-]

InChI

1S/ClH.Li/h1H;/q;+1/p-1

InChI key

KWGKDLIKAYFUFQ-UHFFFAOYSA-M

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Application

Lithium chloride has been used:
  • in the preparation of wash buffer for chromatin immunoprecipitation
  • in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
  • to treat aged myoblast as glycogen synthase kinase (GSK) inhibitor to analyse its effect on wingless/tailess (wnt) signaling

May be used to selectively pre­cipitate RNA.

Packaging

100, 500 g in poly bottle

Biochem/physiol Actions

Lithium chloride has the ability to block glycogen synthase kinase (GSK). It may also possess anti-inflammatory effects at low and non-toxic concentrations.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
A laboratory practical illustrating the use of the ChIP-qPCR method in a robust model: Estrogen receptor alpha immunoprecipitation using Mcf-7 culture cells
Lacazette E
Biochemistry and Molecular Biology Education, 45(2), 152-160 (2017)
mTOR and neuroinflammation
Molecules to Medicine with mTOR, 317-329 (2016)
Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts
Vertino AM, et al.
Molecular Biology of the Cell, 16(4), 2039-2048 (2005)
Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms
Liu R, et al.
Molecular and cellular biology, 28(23), 7236-7244 (2008)
Alessandro Di Maio et al.
EvoDevo, 6, 17-17 (2015-07-15)
Wnt signaling is one of the earliest and most highly conserved regulatory pathways for the establishment of the body axes during regeneration and early development. In regeneration, body axes determination occurs independently of tissue rearrangement and early developmental cues. Modulation...

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