M1318

Sigma-Aldrich

Milnacipran hydrochloride

≥98% (HPLC), solid

Synonym(s):
F 2207, (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride, Midalcipran, Toledomin
Empirical Formula (Hill Notation):
C15H22N2O · HCl
CAS Number:
Molecular Weight:
282.81
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

description

Relative stereochemistry
Store with desiccants

assay

≥98% (HPLC)

form

solid

color

white

solubility

H2O: 19 mg/mL

originator

Cypress Bioscience

storage temp.

2-8°C

SMILES string

Cl[H].CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)c2ccccc2

InChI

1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m1./s1

InChI key

XNCDYJFPRPDERF-PBCQUBLHSA-N

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Serotonin and norepinephrine reuptake inhibitor (SNRI)

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
C Moret et al.
Neuropharmacology, 24(12), 1211-1219 (1985-12-01)
The present study of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane(Z) hydrochloride, was undertaken to determine its biochemical profile. The properties of midalcipran, in inhibiting the uptake of monoamines were tested and compared with that of imipramine. In vitro, midalcipran was found to...
David T Wong et al.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 58, 169-222 (2002-06-25)
Preclinical and clinical studies support the rationale that development of single molecules, which would promote serotonergic and noradrenergic neurotransmission by inhibiting simultaneously the uptake of both monoamines, would potentially result in improved antidepressant drugs. Currently, the dual inhibitors of serotonin...
J Maj et al.
Journal of neural transmission (Vienna, Austria : 1996), 107(11), 1345-1359 (2001-01-06)
Milanacipran (MIL) is a representative of a new class of antidepressants (SNRIs) which inhibit selectively the reuptake of serotonin and noradrenaline but, in contrast to tricyclics, show no affinity for neurotransmitter receptors. The present study was aimed at determining whether...
Hiroshi Kawai et al.
Biological & pharmaceutical bulletin, 41(2), 213-219 (2018-02-02)
Biological rhythms are thought to be related to the pathogenesis and therapy of various diseases including depression. Here we investigated the influence of circadian rhythms on the antidepressant activity of the dual-action serotonin-noradrenaline reuptake inhibitor (SNRI) milnacipran. Rats administered milnacipran...
Junji Uno et al.
Pharmacology, 99(1-2), 89-98 (2016-10-25)
To investigate the potential inhibitory effects of 18 clinically available antidepressants on acetylcholine (ACh)-induced contractions in guinea pig urinary bladder smooth muscle (UBSM) in order to predict whether they may induce voiding impairment. Concentration-response curves for ACh-induced contractions in guinea...

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