Documents

M276

Sigma-Aldrich

Mercaptoethylguanidine sodium succinate

>95%, powder

Synonym(s):
MEG sodium succinate
Linear Formula:
C3H10N3S · C4H4O4Na
Molecular Weight:
259.26
MDL number:
Pricing and availability is not currently available.

assay

>95%

form

powder

color

white

solubility

H2O: soluble

storage temp.

2-8°C

Biochem/physiol Actions

Selective iNOS inhibitor, Peroxynitrite scavenger.

Caution

Hygroscopic

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-36

WGK Germany

3

Certificate of Analysis
Certificate of Origin
G J Southan et al.
British journal of pharmacology, 117(4), 619-632 (1996-02-01)
1. The generation of nitric oxide (NO) from L-arginine by NO synthases (NOS) can be inhibited by guanidines, amidines and S-alkylisothioureas. Unlike most L-arginine based inhibitors, however, some guanidines and S-alkylisothioureas, in particular aminoethylisothiourea (AETU), show selectivity towards the inducible...
C Szabó et al.
The Journal of biological chemistry, 272(14), 9030-9036 (1997-04-04)
Nitric oxide (NO) produced by the inducible nitric-oxide synthase (iNOS) is responsible for some of the pathophysiological alterations during inflammation. Part of NO-related cytotoxicity is mediated by peroxynitrite, an oxidant species produced from NO and superoxide. Aminoguanidine and mercaptoethylguanidine (MEG)...
B Zingarelli et al.
British journal of pharmacology, 120(3), 357-366 (1997-02-01)
1. It has been proposed that in inflammatory conditions, in which both the inducible isoforms of nitric oxide synthase (iNOS) and cyclo-oxygenase (COX-2) are induced, inhibition of NOS also results in inhibition of arachidonic acid metabolism. In the present study...

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