SIN-10, N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine
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500 mg in poly bottle
5 g in poly bottle

Biochem/physiol Actions

Orally active, long acting vasodilator; antianginal; converted by the liver to the active metabolite, SIN-1

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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LOPAC is a registered trademark of Sigma-Aldrich Co. LLC


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dust mask type N95 (US),Eyeshields,Gloves

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NONH for all modes of transport

WGK Germany


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Jerzy Sacha et al.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 17(3), 286-290 (2012-07-24)
Myocardial ischemia during coronary spasm may generate malignant ventricular arrhythmias. The J-wave pattern was suggested to be a marker of a disorder associated with life-threatening arrhythmias. We report the case of a patient with vasospastic angina and J-wave pattern in...
Kandikattu Hemanth Kumar et al.
Neurotoxicology, 34, 150-159 (2012-11-24)
Nitrosylation of tyrosine (3-nitro tyrosine, 3-NT) has been implicated in the pathophysiology of various disorders particularly neurodegenerative conditions and aging. Cyperus rotundus rhizome is being used as a traditional folk medicine to alleviate a variety of disorders including neuronal stress....
Laurine Mattart et al.
Cellular signalling, 24(1), 199-213 (2011-09-29)
Endothelial dysfunction is associated with the formation of peroxynitrite, described to be toxic. Recent data also suggests that peroxynitrite is able to activate the protective Nrf2 pathway and/or the unfolded protein response (UPR). The aim of our work was to...
Stefanie Ruhs et al.
Free radical biology & medicine, 53(5), 1088-1100 (2012-07-04)
The mineralocorticoid receptor (MR) plays an important role in salt and water homeostasis and pathological tissue modifications, such as cardiovascular and renal fibrosis. Importantly, MR activation by aldosterone per se is not sufficient for the deleterious effects but requires the...
Ana B Fernandes et al.
Canadian journal of physiology and pharmacology, 90(7), 887-894 (2012-06-15)
Insulin sensitivity is maximal in the postprandial state, decreasing with a fasting period through a mechanism that is dependent on the integrity of the hepatic parasympathetic nerves/nitric oxide (NO) production and increased hepatic glutathione (GSH) levels. GSH and NO react...

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