M7319

Sigma-Aldrich

ML 10302

≥98%, solid

Synonym(s):
2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate
Empirical Formula (Hill Notation):
C15H21ClN2O3
CAS Number:
Molecular Weight:
312.79
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

assay

≥98%

form

solid

color

white to off-white

solubility

DMSO: >20 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

COc1cc(N)c(Cl)cc1C(=O)OCCN2CCCCC2

InChI

1S/C15H21ClN2O3/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18/h9-10H,2-8,17H2,1H3

InChI key

RVFIAQAAZUEPPE-UHFFFAOYSA-N

Gene Information

rat ... Htr3a(79246), Htr4(25324)

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Potent, selective 5-HT4 serotonin receptor agonist

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Jean-Louis Soulier et al.
Journal of medicinal chemistry, 48(20), 6220-6228 (2005-09-30)
Recently, human 5-HT4 receptors have been demonstrated to form constitutive dimers in living cells. To evaluate the role of dimerization on the 5-HT4 receptor function, we investigated the conception and the synthesis of bivalent molecules able to influence the dimerization...
F De Ponti et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 13(6), 543-553 (2002-03-21)
5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also be involved. Differences may exist between the small bowel and colon. Our aims were: (i) to compare the...
D Yang et al.
Journal of medicinal chemistry, 40(4), 608-621 (1997-02-14)
A number of benzoates derived from 4-amino-5-chloro-2-methoxybenzoic acid and substituted 1-piperidineethanol were synthesized and found to be potent 5-HT4 receptor agonists in the electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum and the rat esophagus muscle. Monosubstitution...

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