M9420

Sigma-Aldrich

7-Methoxycoumarin-4-acetyl-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-(2,4-dinitrophenyl)Lys amide

≥97% (HPLC)

Empirical Formula (Hill Notation):
C79H105N19O19S
CAS Number:
Molecular Weight:
1656.86
MDL number:
PubChem Substance ID:

assay

≥97% (HPLC)

form

powder

solubility

0.05 M acetic acid: 1 mg/mL, clear

storage temp.

−20°C

SMILES string

CCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C2CCCN2C(=O)[C@H](CCCCN)NC(=O)C3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)CC4=CC(=O)Oc5cc(OC)ccc45)C(=O)N[C@@H](Cc6c[nH]c7ccccc67)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCNc8ccc(cc8[N+]([O-])=O)[N+]([O-])=O)C(N)=O

InChI

1S/C79H105N19O19S/c1-5-15-57(71(104)93-62(39-48-44-86-54-17-7-6-16-52(48)54)74(107)91-58(31-37-118-4)72(105)89-56(69(81)102)18-9-11-33-84-55-30-25-49(97(112)113)42-65(55)98(114)115)90-70(103)45(2)87-73(106)61(38-46-23-26-50(99)27-24-46)94-76(109)64-22-14-36-96(64)78(111)60(19-8-10-32-80)92-75(108)63-21-13-35-95(63)77(110)59(20-12-34-85-79(82)83)88-67(100)40-47-41-68(101)117-66-43-51(116-3)28-29-53(47)66/h6-7,16-17,23-30,41-45,56-64,84,86,99H,5,8-15,18-22,31-40,80H2,1-4H3,(H2,81,102)(H,87,106)(H,88,100)(H,89,105)(H,90,103)(H,91,107)(H,92,108)(H,93,104)(H,94,109)(H4,82,83,85)/t45-,56-,57-,58-,59-,60-,61-,62-,63-,64-/m0/s1

InChI key

PMQNLFGGVGXOSM-BULAGXLTSA-N

Gene Information

human ... MMP3(4314)
mouse ... MMP3(17392)
rat ... MMP3(171045)

Amino Acid Sequence

MOCAc-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys-DNPNH2

Substrates

Fluorogenic substrate for stromelysin-1 (matrix metalloproteinase 3).

Certificate of Analysis

Certificate of Origin

H Nagase et al.
The Journal of biological chemistry, 269(33), 20952-20957 (1994-08-19)
Members of the matrix metalloproteinase (MMP) family have been implicated in disease states such as arthritis, periodontal disease, and tumor cell invasion and metastasis. Stromelysin 1 (MMP-3) has a broad substrate specificity and participates in the activation of several MMP...

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