N1783

Sigma-Aldrich

Nitric Oxide Synthase, Inducible from mouse

from mouse macrophages, buffered aqueous glycerol solution

Synonym(s):
NOS II, iNOS, Inducible Nitric Oxide Synthase, macNOS
Enzyme Commission number:
MDL number:
Pricing and availability is not currently available.

form

buffered aqueous glycerol solution

specific activity

≥1.0 units/mg protein

mol wt

130 kDa (homodimer)

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... Nos2(18126)

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Biochem/physiol Actions

NOS is responsible for the biosynthesis of nitric oxide from L-arginine. iNOS is not calcium/calmodulin dependent and has a Km = 16 μM for L-arginine.

Unit Definition

One unit of enzyme produces 1 nmole of nitric oxide per minute at 37 °C in 50 mM HEPES, pH 7.4, containing 5 μM oxyhemoglobin, 0.1 mM NADPH, 1 mM arginine, 1 mM magnesium acetate, 12 μM tetrahydrobiopterin, and 170 μM DTT.

Physical form

Solution in 50 mM HEPES, pH 7.4, with 10% glycerol.

WGK Germany

1

Stefanie Geisler et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 33(11), 2688-2700 (2007-12-21)
Blockade of monoamine transporters by cocaine should not necessarily lead to certain observed consequences of cocaine administration, including increased firing of ventral mesencephalic dopamine (DA) neurons and accompanying impulse-stimulated release of DA in the forebrain and cortex. Accordingly, we hypothesize...

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