All Photos(1)

N3285

Sigma-Aldrich

N-(NBD-Aminohexanoyl)-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine sodium salt

Synonym(s):
N-(NBD-aminocaproyl)-1,2-dioleoyl-sn-glycero-3-phosphosphoethanolamine sodium salt
Empirical Formula (Hill Notation):
C53H89N5NaO12P
Molecular Weight:
1042.26
MDL number:

shipped in

dry ice

storage temp.

−20°C

Biochem/physiol Actions

1,2-dioleoyl-sn-glycero-3-phosphosphoethanolamine (DOPE) is a widely used lipid in the construction of lipid structures such as micelles, liposomes, lipid bilayers and lipid-based gene transfection vectors. N-(NBD-aminocaproyl)-1,2-dioleoyl-sn-glycero-3-phosphosphoethanolamine sodium salt may be used as a fluorescent phospholipid membrane and lipoplex probe.

Other Notes

Fluorescently labeled fatty acid phospholipid membrane probe

Certificate of Analysis

Certificate of Origin

J P Neves Silva et al.
Journal of fluorescence, 18(2), 555-562 (2007-12-25)
Lipoplexes are commonly used as delivery systems in vitro and in vivo, the role of a neutral lipid as helper being of extreme importance in these systems. Cationic liposomes composed of dioctadecyldimethylammonium bromide (DODAB) with monoolein (MO) as a helper...
V S Malinin et al.
Biochemistry, 40(28), 8292-8299 (2001-07-11)
A number of fluorescent probes have been used to follow membrane fusion events, particularly intermixing of lipids. None of them is ideal. The most popular pair of probes is NBD-PE and Rh-PE, in which the fluorescent groups are attached to...
J P Neves Silva et al.
Biochimica et biophysica acta, 1808(10), 2440-2449 (2011-07-27)
DNA/Cationic liposome complexes (lipoplexes) have been widely used as non-viral vectors for transfection. Neutral lipids in liposomal formulation are determinant for transfection efficiency using these vectors. In this work, we studied the potential of monoolein (MO) as helper lipid for...
Catarina Madeira et al.
Biochimica et biophysica acta, 1808(11), 2694-2705 (2011-08-09)
Since the first reported transfection studies using cationic liposomes in 1987, significant advances have been made on the understanding of the physical properties of DNA/cationic liposome complexes (lipoplexes) in order to improve their transfection efficiencies. In this review a critical...
Robert Blumenthal et al.
Chemistry and physics of lipids, 116(1-2), 39-55 (2002-07-03)
Fluorescent lipid probes are widely used in the observation of viral membrane fusion, providing a sensitive method to study fusion mechanism(s). Due to the wealth of data concerning liposome fusion, a variety of fusion assays has been designed including fluorescent...

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