P0021

Sigma-Aldrich

Pantoprazole sodium hydrate

≥98% (HPLC)

Synonym(s):
Protonix hydrate, Pantozol hydrate, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate
Empirical Formula (Hill Notation):
C16H14F2N3O4S · Na · xH2O
CAS Number:
Molecular Weight:
405.35 (anhydrous basis)
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

application(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white to off-white

solubility

H2O: ≥20 mg/mL

originator

Novartis

storage temp.

−20°C

SMILES string

O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC

InChI

1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;

InChI key

CGJRLPRCWSHOFU-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495), ATP4B(496)

Related Categories

Application

Pantoprazole sodium hydrate has been used:
  • as a standard in high-performance liquid chromatography (HPLC){58
  • as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
  • to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.
Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.
Pantoprazole is a gastric proton pump inhibitor.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Pantoprazole
<BIG>Perry CM and Ibbotson T</BIG>
Drugs, 101-132 (2003)
<BIG>Rissling O</BIG>
Interaction of Mycophenolic Acid and Pantoprazole: A Pharmacokinetic Crossover Study (2017)
Analysis of ibuprofen, pantoprazole, and itopride combination therapeutic drugs in human plasma by solid phase membrane microtip extraction and high-performance liquid chromatography methods using new generation core shell C18 column
Ali I, et al.
Journal of Liquid Chromatography and Related Technologies, 39(7), 339-345 (2016)
Khamushavalli Geeviman et al.
Cellular and molecular neurobiology, 38(8), 1491-1504 (2018-10-12)
Gastric H+/K+-ATPase or vacuolar-ATPases (V-ATPases) are critical for the cancer cells survival and growth in the ischemic microenvironment by extruding protons from the cell. The drugs which inhibit V-ATPases are known as proton pump inhibitors (PPIs). In the present study...
A Fitton et al.
Drugs, 51(3), 460-482 (1996-03-01)
Pantoprazole is an irreversible proton pump inhibitor which, at the therapeutic dose of 40mg, effectively reduces gastric acid secretion. In controlled clinical trials, pantoprazole (40mg once daily) has proved superior to ranitidine (300mg once daily or 150mg twice daily) and...

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