P1431

Sigma-Aldrich

Calmodulin from bovine testes

BioUltra, ≥98% (SDS-PAGE), lyophilized powder

Synonym(s):
Phosphodiesterase 3′:5′-cyclic nucleotide activator, CaM
CAS Number:
MDL number:
NACRES:
NA.61
Pricing and availability is not currently available.

biological source

bovine testis

Quality Level

product line

BioUltra

assay

≥98% (SDS-PAGE)

form

lyophilized powder

application(s)

cell analysis: suitable
ligand binding assay: suitable

impurities

salt, essentially free

storage temp.

−20°C

Gene Information

cow ... CALM3(520277)

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Application

Calmodulin from bovine testes has been shown to activate a plasma membrane (Ca2+Mg2+)-ATPase in porcine aortic endothelial cells.

Biochem/physiol Actions

Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

E J McConnell et al.
Circulation research, 86(2), 191-197 (2000-02-10)
Plasma membrane (Ca(2+)+Mg(2+))-ATPase and Ca(2+) transport activities, best characterized in human erythrocytes, are stimulated by calmodulin and thought to play a crucial role in the termination of cellular Ca(2+) signaling in all cells. In plasma membranes isolated from cultured porcine...
Elisha R Injeti et al.
American journal of physiology. Heart and circulatory physiology, 295(6), H2289-H2298 (2008-10-07)
Postnatal decreases in vascular reactivity involve decreases in the thick filament component of myofilament calcium sensitivity, which is measured as the relationship between cytosolic calcium concentration and myosin light chain (MLC20) phosphorylation. The present study tests the hypothesis that downregulation...
Maya A Olshina et al.
Antioxidants & redox signaling, 32(9), 636-655 (2020-01-07)
Aims: The protein degradation machinery plays a critical role in the maintenance of cellular homeostasis, preventing the accumulation of...

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