P3032

Sigma-Aldrich

Penicillin G sodium salt

powder, BioReagent, suitable for cell culture

Synonym(s):
Benzylpenicillin sodium salt
Empirical Formula (Hill Notation):
C16H17N2NaO4S
CAS Number:
Molecular Weight:
356.37
Beilstein/REAXYS Number:
3834217
EC Number:
MDL number:
eCl@ss:
34010400
PubChem Substance ID:
NACRES:
NA.76
Pricing and availability is not currently available.

product line

BioReagent

form

powder

potency

≥1477 units per mg

application(s)

cell culture | mammalian: suitable

solubility

H2O: 100 mg/mL (Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for extended periods. Solutions are stable at 37°C for 3 days.)

Mode of action

cell wall synthesis | interferes

antibiotic activity spectrum

Gram-positive bacteria

SMILES string

Na+.HC@12SC(C)(C)C@@H(N1C(=O)C@H2NC(=O)Cc3ccccc3)C(O-)=O

InChI

1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChI key

FCPVYOBCFFNJFS-LQDWTQKMSA-M

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General description

Chemical structure: ß-lactam

Application

Penicillin G is a narrow spectrum natural antibiotic. It is effective against Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. It has been used to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility and in cell culture both alone and combined with streptomycin and other antibiotics.

Biochem/physiol Actions

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.

Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.

Caution

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H2O at 100 mg/mL.

Other Notes

1mu,10mu,25mu,100mu
Keep container tightly closed in a dry and well-ventilated place.Product contains Penicillin Keep in a dry place.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xn

Risk Statement

42/43

Safety Statement

22-36/37-45

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Certificate of Analysis
Certificate of Origin
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Articles
Inhibition of Cell Wall Biosynthesis by Antibiotics
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