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P4622

Sigma-Aldrich

Anti-Potassium Channel Kv3.3 (KNC3) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat, mouse, human

application(s)

western blot: 1:200 using rat brain membranes

conjugate

unconjugated

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... KCNC3(3748)
mouse ... Kcnc3(16504)
rat ... Kcnc3(117101)

Specificity

Recognizes splice variant KV3.3-1.

Immunogen

synthetic peptide corresponding to amino acid residues 701-718 of rat KV3.3. The sequence is identical in human and mouse.

Physical form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

Certificate of Analysis

Certificate of Origin

B Rudy et al.
Trends in neurosciences, 24(9), 517-526 (2001-08-17)
Analysis of the Kv3 subfamily of K(+) channel subunits has lead to the discovery of a new class of neuronal voltage-gated K(+) channels characterized by positively shifted voltage dependencies and very fast deactivation rates. These properties are adaptations that allow...
Hiroshi Matsukawa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(20), 7677-7684 (2003-08-22)
Micelacking both Kv3.1 and both Kv3.3 K+ channel alleles display severe motor deficits such as tremor, myoclonus, and ataxic gait. Micelacking one to three alleles at the Kv3.1 and Kv3.3 loci exhibit in an allele dose-dependent manner a modest degree...

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