All Photos(1)

P4888

Sigma-Aldrich

4α-Phorbol

powder

Synonym(s):
4α-PHR, 4α,9α,12β,13α,20-pentahydroxytiglia-1,6-dien-3-one, Isophorbol
Empirical Formula (Hill Notation):
C20H28O6
CAS Number:
Molecular Weight:
364.43
MDL number:
PubChem Substance ID:

form

powder

color

white

storage temp.

−20°C

SMILES string

C[C@@H]1[C@@H](O)[C@]2(O)[C@H]([C@@H]3C=C(CO)C[C@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C

InChI

1S/C20H28O6/c1-9-5-13-18(24,15(9)22)7-11(8-21)6-12-14-17(3,4)20(14,26)16(23)10(2)19(12,13)25/h5-6,10,12-14,16,21,23-26H,7-8H2,1-4H3/t10-,12+,13-,14-,16-,18+,19-,20-/m1/s1

InChI key

QGVLYPPODPLXMB-FYYCTCHMSA-N

Application

Phorbol that is not biologically active; can be used as a negative control

Certificate of Analysis

Certificate of Origin

Emad Afrasiabi et al.
Molecular and cellular endocrinology, 292(1-2), 26-35 (2008-06-11)
Phorbol 12-myristate 13-acetate (PMA) is known to affect a variety of cellular processes, including cell proliferation, differentiation, and migration. PMA has been shown to promote antiproliferative and antimigratory effects in many types of cancer cells. Our findings show that PMA...
Vijay Lyall et al.
Journal of neurophysiology, 102(3), 1591-1605 (2009-06-26)
The regulation of the benzamil (Bz)-insensitive salt taste receptor was investigated by intracellular Ca2+ ([Ca2+]i), protein kinase C (PKC), and the Ca2+-dependent serine-threonine phosphatase, calcineurin (PP2B), by monitoring chorda tympani taste nerve responses to 0.1 M NaCl solutions containing Bz...
Xowi K M S Mwimbi et al.
FEBS letters, 530(1-3), 31-36 (2002-10-22)
In medium 199, ciliary beat frequency (CBF) in human nasal epithelium declines to 60% of baseline by 2 h and 1 nM phorbol-12-myristate-13-acetate (PMA) doubles the rate of decline by activating protein kinase C (PKC). We find that a reported...
Paul A Wender et al.
Science (New York, N.Y.), 320(5876), 649-652 (2008-05-03)
Although antiretroviral therapies have been effective in decreasing active viral loads in AIDS patients, the persistence of latent viral reservoirs prevents eradication of the virus. Prostratin and DPP (12-deoxyphorbol-13-phenylacetate) activate the latent virus and thus represent promising adjuvants for antiviral...
Francesco Buonocore et al.
Marine biotechnology (New York, N.Y.), 8(1), 80-85 (2005-10-27)
Continuous cell lines represent an important tool both for biological studies and for their applications in marine biotechnology. In this article we describe the production and characterization of a continuous adherent cell line, named DLEC, derived from early embryos of...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service