P8227

Sigma-Aldrich

1,3-PBIT dihydrobromide

Synonym(s):
Phenylene-1,3-bis(ethane-2-isothiourea) dihydrobromide
Empirical Formula (Hill Notation):
C12H18N4S2 · 2HBr
Molecular Weight:
444.25
PubChem Substance ID:
Pricing and availability is not currently available.

storage temp.

−20°C

SMILES string

Br.Br.NC(=N)SCCc1cccc(CCSC(N)=N)c1

Gene Information

human ... NOS2(4843), NOS3(4846)

Biochem/physiol Actions

Potent inducible NOS (iNOS) inhibitor, Ki = 47 nM; endothelial NOS (eNOS) inhibitor Ki = 9 μM.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-36

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
E P Garvey et al.
The Journal of biological chemistry, 269(43), 26669-26676 (1994-10-28)
S-Ethylisothiourea was a potent competitive inhibitor of human nitric oxide synthase (NOS), with Ki values of 17, 36, and 29 nM for the inducible (i), endothelial (e), and neuronal (n) isozymes, respectively. Unlike some potent inhibitors of NOS, no time...

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