1,4-PBIT dihydrobromide

1,4-Phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide
Empirical Formula (Hill Notation):
C12H18N4S2 · 2HBr
CAS Number:
Molecular Weight:
MDL number:
Pricing and availability is not currently available.

storage temp.


SMILES string


Gene Information

human ... NOS2(4843), NOS3(4846)

Biochem/physiol Actions

Potent inducible NOS (iNOS) inhibitor, Ki = 7.4 nM; endothelial NOS (eNOS) inhibitor Ki = 0.36 μM.
Certificate of Analysis
Certificate of Origin
E P Garvey et al.
The Journal of biological chemistry, 269(43), 26669-26676 (1994-10-28)
S-Ethylisothiourea was a potent competitive inhibitor of human nitric oxide synthase (NOS), with Ki values of 17, 36, and 29 nM for the inducible (i), endothelial (e), and neuronal (n) isozymes, respectively. Unlike some potent inhibitors of NOS, no time...

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