R1658

Sigma-Aldrich

RS-102221 hydrochloride hydrate

≥98% (HPLC)

Synonym(s):
8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonam ido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2, 4-dione hydrochloride hydrate
Empirical Formula (Hill Notation):
C27H31F3N4O7S·HCl · xH2O
Molecular Weight:
649.08 (anhydrous basis)
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.COc1cc(OC)c(cc1NS(=O)(=O)c2ccc(cc2)C(F)(F)F)C(=O)CCCCN3CCC4(CC3)NC(=O)NC4=O

InChI

1S/C27H31F3N4O7S.ClH.H2O/c1-40-22-16-23(41-2)20(33-42(38,39)18-8-6-17(7-9-18)27(28,29)30)15-19(22)21(35)5-3-4-12-34-13-10-26(11-14-34)24(36)31-25(37)32-26;;/h6-9,15-16,33H,3-5,10-14H2,1-2H3,(H2,31,32,36,37);1H;1H2

InChI key

IGACJTZTAQBWKN-UHFFFAOYSA-N

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

RS-102221 is a selective, high affinity 5-HT2C receptor antagonist.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

RIDADR

NONH for all modes of transport

WGK Germany

3

Certificate of Analysis
Certificate of Origin
Chris M Panzini et al.
Journal of neurochemistry, 143(6), 708-721 (2017-09-28)
In humans a chromosomal hemideletion of the 16p11.2 region results in variable neurodevelopmental deficits including developmental delay, intellectual disability, and features of autism spectrum disorder (ASD). Serotonin is implicated in ASD but its role remains enigmatic. In this study we...

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