R2156

Sigma-Aldrich

Relaxin-1 human

recombinant, expressed in E. coli, >95% (SDS-PAGE), lyophilized powder

Synonym(s):
Relaxin 1, RLN1, RLXH1
CAS Number:
NACRES:
NA.26
Pricing and availability is not currently available.

Quality Level

biological source

human

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

(Contains two disulfide-linked subunits: A chain ~2.8 kDa B chain ~3.3 kDa)

application(s)

cell culture | mammalian: suitable

suitability

endotoxin tested

storage temp.

−20°C

Gene Information

human ... RLN1(6013)

General description

Cell signaling hormone that is prominent in the prostate, and belongs to the insulin superfamily

Biochem/physiol Actions

Relaxin has been shown to have antifibrotic effects in renal fibroblasts through mechanisms that increase collagenase activity and via TGF-β signaling.
Relaxin 1 may function in regulating blood pressure, controlling heart rate, and releasing oxytocin and vasopressin

Physical form

Lyophilized powder containing BSA

Reconstitution

In Phosphate buffered saline solution containing at least 0.1% serum albumin. The concentration should be ≥10 μg/mL

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Rosemary Masterson et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 19(3), 544-552 (2004-02-10)
Renal fibroblasts are important effector cells in tubulointerstitial fibrosis, with experimental antifibrotic strategies focusing on the functional down-regulation of these cells. Several experimental models of fibrosis have provided evidence for the effectiveness of the polypeptide hormone relaxin as a potential...

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