R2533

Sigma-Aldrich

RS-127445 hydrochloride

≥98% (HPLC), powder

Synonym(s):
2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
Empirical Formula (Hill Notation):
C17H16FN3 · HCl
CAS Number:
Molecular Weight:
317.79
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥20 mg/mL

originator

Roche

storage temp.

2-8°C

SMILES string

Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23

InChI

1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H

InChI key

MKJPYBJBPRFMHL-UHFFFAOYSA-N

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Target Organs

Respiratory system

Hazard Codes

T

Risk Statement

25-36

Safety Statement

26-45

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin

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