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Ristomycin monosulfate

≥90% ristocetin A basis (balance primarily Ristocetin B)

Ristocetin sulfate salt
Empirical Formula (Hill Notation):
C95H110N8O44 · H2SO4
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:

Quality Level


≥90% ristocetin A basis (balance primarily Ristocetin B)

Mode of action

cell wall synthesis | interferes

storage temp.


SMILES string




InChI key


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General description

Ristomycin/ristocetin is a type III glycopeptide. It is a highly glycosylated glycopeptide, previously found in Amycolatopsis lurida.


Ristomycin monosulfate has been used:
  • to activate platelet and induce platelet aggregation
  • to study the aggregation responses of platelets from buffalo, horse, pig and sheep
  • in in-house ristocetin cofactor von Willebrand factor (VWF:RCo) assay to measure glycoprotein Ib (GpIb) binding activity


100, 250 mg in poly bottle

Biochem/physiol Actions

Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.
Ristomycin possesses antibacterial activity. It may be used to diagnose von Willebrand disease and Bernard-Soulier syndrome. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb) and decreased RIPA might reduce platelet adhesion to vascular subendothelium and improve bleeding associated with uremia in patients with chronic hemodialysis.

Other Notes

Glycopeptide antibiotic complex

Storage Class Code

13 - Non Combustible Solids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Bleeding Symptoms and von Willebrand Factor Levels: 30-Year Experience in a Tertiary Care Center
Moonla C, et al.
Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (2019)
A Kasirer-Friede et al.
Thrombosis and haemostasis, 80(3), 428-436 (1998-10-06)
We recently reported that washed platelets (WP) activated with ADP and expressing surface-bound vWF aggregated in flow through small tubes or in a cylindrical couette device at physiological shear rates of G = 300 s(-1)-1000 s(-1) in the absence of...
Elevated plasma glycocalicin levels and decreased ristocetin-induced platelet agglutination in hemodialysis patients
Himmelfarb J, et al.
American Journal of Kidney Diseases, 32(1), 132-138 (1998)
Species variability in platelet aggregation response to different agonists
Pelagalli A, et al.
Journal of Comparative Pathology, 127(2-3), 126-132 (2019)
T Kitaguchi et al.
Biochemical and biophysical research communications, 261(3), 784-789 (1999-08-12)
Platelet glycoprotein (GP) Ib/IX/V complex is a receptor for von Willebrand factor (vWf), which plays a crucial role in primary hemostasis by mediating platelet adhesion to injured blood vessels. We have expressed in CHO cells a fragment of GPIba that...

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