Christopher M Bailey et al.
Journal of medicinal chemistry, 56(10), 3959-3968 (2013-05-11)
Human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) is a major target for currently approved anti-HIV drugs. These drugs are divided into two classes: nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs). This study illustrates the synthesis and...
Xiu-Juan Jiao et al.
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 26(6), 453-455 (2013-05-01)
To characterize genotypic resistance within HBV RT region in chronic hepatitis B (CHB) patients with nucleos(t)ide analogue (NA) treatment. Serum samples of 229 CHB patients with NA treatment were obtained. Full-length HBV RT sequences were amplified, sequenced and analyzed, on...
TERT hypermethylation: biomarker in paediatric brain tumours.
Scott J Diede
The Lancet. Oncology, 14(6), 447-448 (2013-04-20)
Jiansen Jiang et al.
Nature, 496(7444), 187-192 (2013-04-05)
Telomerase adds telomeric repeats to chromosome ends using an internal RNA template and a specialized telomerase reverse transcriptase (TERT), thereby maintaining genome integrity. Little is known about the physical relationships among protein and RNA subunits within a biologically functional holoenzyme....
Ausubel, F., et al.
Short Protocols in Molecular Biology, 14-14 (1995)