S0501

Sigma-Aldrich

Sodium nitroprusside dihydrate

Synonym(s):
Nitroprusside sodium, SNP, Sodium nitroferricyanide, Sodium pentacyanonitrosylferrate
Linear Formula:
Na2Fe(CN)5NO · 2H2O
CAS Number:
Molecular Weight:
297.95
EC Number:
MDL number:
Pricing and availability is not currently available.

SMILES string

O.O.Na+.Na+.O=NFe--(C#N)(C#N)(C#N)(C#N)C#N

InChI

1S/5CN.Fe.NO.2Na.2H2O/c5*1-2;;1-2;;;;/h;;;;;;;;;2*1H2/q;;;;;2*-1;2*+1;;

InChI key

OIRZWVYIQXBRFC-UHFFFAOYSA-N

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Biochem/physiol Actions

Releases NO in vivo, thus activating guanylyl cyclase, ADP-ribosyltransferase, and cyclooxygenase and inhibiting lipoxygenase. Induces vasodilation and inhibits platelet aggregation.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

T

Risk Statement

25

Safety Statement

45

RIDADR

UN 3288 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

D Salvemini et al.
The Journal of clinical investigation, 97(11), 2562-2568 (1996-06-01)
We have evaluated the contributions of nitric oxide (NO) and prostacyclin (PGI2) in the in vivo antiplatelet effects of clinically useful nitrovasodilators. In rats, intravenous infusion of three NO donors, glyceryl trinitrate, sodium nitroprusside, or 3'-morpholinosydnonimine, the stable metabolite of...
M Maccarrone et al.
Biochemical and biophysical research communications, 219(1), 128-133 (1996-02-06)
The nitric oxide (N0-releasing agents sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) inhibit dioxygenase activity of lipoxygenase in human platelets and human CHP100 neuroblastoma cells, leading the latter to necrosis. The effect of both NO-donors on the dioxygenase reaction was investigated...
Feelisch, M.
Journal of Cardiovascular Pharmacology, 17, S25-S25 (1991)
B Brüne et al.
The Journal of biological chemistry, 264(15), 8455-8458 (1989-05-25)
Sodium nitroprusside is a vasodilator and an inhibitor of platelet activation. It is thought that these effects are mediated by the spontaneous release of nitric oxide and stimulation of cytosolic guanylate cyclase. We have found that sodium nitroprusside (5-200 microM)...
F J Azula et al.
Molecular pharmacology, 50(2), 367-379 (1996-08-01)
Different drugs that elevate the cGMP levels inhibit the agonist-induced platelet activation. The mechanisms of action of cGMP probably include inhibition of both phospholipase C and the increase in intracellular Ca2+ concentration, and these effects seem to be mediated by...

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