S0693

Sigma-Aldrich

SB 204741

>98% (HPLC)

Synonym(s):
N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea
Empirical Formula (Hill Notation):
C14H14N4OS
CAS Number:
Molecular Weight:
286.35
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

assay

>98% (HPLC)

form

solid

color

off-white to tan

solubility

DMSO: soluble >20 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1

InChI

1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)

InChI key

USFUFHFQWXDVMH-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), DRD3(1814), DRD5(1816), HTR1E(3354), HTR2A(3356), HTR2B(3357), HTR2C(3358)
rat ... Adra1a(29412), Gabra2(29706), Htr1a(24473), Htr2b(29581), Htr3a(79246)

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

5-HT2B serotonin receptor antagonist.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Ercan Ozdemir et al.
Bioelectromagnetics, 40(5), 319-330 (2019-06-04)
Much evidence demonstrates the antinociceptive effect of magnetic fields (MFs). However, the analgesic action mechanism of the electromagnetic field (EMF) is not exactly understood. The aim of the present study was to investigate the effects of 5-HT1 and 5-HT2 receptor...
Annika Gocht et al.
Transplant immunology, 49, 43-53 (2018-04-13)
Cardiac allograft vasculopathy (CAV) is the main obstacle for long-term survival after heart transplantation. Alloimmune mediated chronic vascular rejection results in several mechanisms like platelet activation, immigration of inflammatory cells through the endothelial layer and proliferation and migration of smooth...
Qiqi Yang et al.
Scientific reports, 8(1), 8495-8495 (2018-06-02)
Activation of hepatic stellate cells (HSC) plays a crucial role in the liver disease progression from liver fibrosis/cirrhosis to cancer. Here, we found a rapid change of microenvironment after kras V12 -induction in zebrafish liver with progressively increased stromal cell...
Katharina J Gerhold et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(26), 9580-9594 (2015-07-03)
Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, despite its wide clinical use, little is known about the synaptic effects...

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