S1013

Sigma-Aldrich

(−)-Scopolamine hydrochloride

≥90% (HPLC), powder

Synonym(s):
Hyoscine hydrochloride, Scopine tropate
Empirical Formula (Hill Notation):
C17H21NO4 · HCl
CAS Number:
Molecular Weight:
339.81
Beilstein/REAXYS Number:
4168778
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

assay

≥90% (HPLC)

form

powder

optical activity

[α]25/D ~−27°, c = 1 in H2O(lit.)

color

white

solubility

H2O: 50 mg/mL

SMILES string

Cl.[H][C@]12C[C@H](C[C@]([H])(N1C)[C@]3([H])O[C@]23[H])OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C17H21NO4.ClH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/m1./s1

InChI key

KXPXJGYSEPEXMF-MOUKNHLCSA-N

Gene Information

human ... CHRM1(1128)

Looking for similar products? Visit Product Comparison Guide

Packaging

1, 5 g in glass bottle

Biochem/physiol Actions

Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.

Caution

The powder is stable at least four years stored at room temperature.

Certificate of Analysis

Certificate of Origin

null
Yi-Kuei Wong et al.
Pharmacology, 93(5-6), 278-285 (2014-08-30)
Methamphetamine abuse may produce cognitive impairment. Baicalein, a bioactive flavonoid, has antioxidative, anti-inflammatory and neuroprotective effects. This study examined the effects of baicalein pretreatment on memory performance in the passive avoidance test after either one dose or an acute binge...
Agnese Cristini et al.
Cell reports, 28(12), 3167-3181 (2019-09-19)
Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenerative disorders, our understanding of how transcription produces DNA double-strand breaks (DSBs) is limited. Transcription-blocking topoisomerase I cleavage complexes (TOP1ccs) are frequent events that prime DSB production in...
Panagiotis Karras et al.
Cancer cell, 35(1), 46-63 (2018-12-26)
Modulators of mRNA stability are not well understood in melanoma, an aggressive tumor with complex changes in the transcriptome. Here we report the ability of p62/SQSTM1 to extend mRNA half-life of a spectrum of pro-metastatic factors. These include FERMT2 and...
José A S Luis et al.
Acta pharmaceutica (Zagreb, Croatia), 64(2), 233-245 (2014-06-11)
Seven new compounds have been synthetized in satisfactory yields (51-78 %) through the treatment of mesoionic 1,3-thiazolium-5-thiolate (4a-d) and 1,3,4-thiadiazolium- 5-thiolate (10a,b) with chloroacetic acid or methyl iodide: 1,3,4-thiadiazolium-5-methylthio- (11) and 5-thioacetate (12). The structure of the title compounds was...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service