S150

Sigma-Aldrich

Spermine–Nitric oxide complex

source of nitric oxide

Synonym(s):
N-4-1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazinobutyl-1,3-propanediamine, SPER/NO, Spermine NONOate
Empirical Formula (Hill Notation):
C10H26N6O2
CAS Number:
Molecular Weight:
262.35
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level

assay

(NMR)

form

powder

storage condition

desiccated

color

white

solubility

methanol: ≥1 mg/mL
H2O: ≥2 mg/mL

εmax

8500 at 252 nm

shipped in

dry ice

storage temp.

−20°C

SMILES string

NCCCN(N(N=O)O)CCCCNCCCN

InChI

1S/C10H26N6O2/c11-5-3-8-13-7-1-2-9-15(10-4-6-12)16(18)14-17/h13,18H,1-12H2

InChI key

QPIOUFBAROSIAN-UHFFFAOYSA-N

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Related Categories

Packaging

25 mg in glass bottle

Application

Used to produce a controlled release of nitric oxide in solution.

Other Notes

air sensitive

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

Certificate of Analysis
Certificate of Origin
Payam Dibaj et al.
Glia, 58(9), 1133-1144 (2010-05-15)
To understand the pathomechanisms of spinal cord injuries will be a prerequisite to develop efficient therapies. By investigating acute lesions of spinal cord white matter in anesthetized mice with fluorescently labeled microglia and axons using in vivo two-photon laser-scanning microscopy...
A S Deshmukh et al.
Diabetologia, 53(6), 1142-1150 (2010-03-30)
We investigated the direct effect of a nitric oxide donor (spermine NONOate) on glucose transport in isolated human skeletal muscle and L6 skeletal muscle cells. We hypothesised that pharmacological treatment of human skeletal muscle with N-(2-aminoethyl)-N-(2-hydroxy-2-nitrosohydrazino)-1,2-ethylenediamine (spermine NONOate) would increase...
Nadia Sachewsky et al.
Stem cells and development, 23(20), 2469-2481 (2014-05-29)
Temporally distinct populations of neural stem cells (NSCs; embryonic and adult) display the cardinal stem cell properties of self-renewal and multipotentiality; however, their relative frequency and cell kinetics vary through development and into old age. We asked whether changes in...
Travis J Bourret et al.
Scientific reports, 7(1), 15083-15083 (2017-11-10)
The PhoPQ two-component regulatory system coordinates the response of Salmonella enterica serovar Typhimurium to diverse environmental challenges encountered during infection of hosts, including changes in Mg
Erica Miraglia et al.
Reproduction (Cambridge, England), 141(1), 47-54 (2010-10-23)
Nitric oxide (NO), a modulator of several physiological processes, is involved in different human sperm functions. We have investigated whether NO may stimulate the motility of human spermatozoa via activation of the soluble guanylate cyclase (sGC)/cGMP pathway. Sperm samples obtained...

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