S201

Sigma-Aldrich

SB-224289 hydrochloride

solid

Synonym(s):
SB-224289A, 1′-Methyl-5-[[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4′-piperidine] hydrochloride
Empirical Formula (Hill Notation):
C32H32N4O3 · HCl
CAS Number:
Molecular Weight:
557.08
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

form

solid

color

off-white

solubility

DMSO: 4.5 mg/mL
H2O: insoluble

SMILES string

Cl.CN1CCC2(CC1)COc3cc4CCN(C(=O)c5ccc(cc5)-c6ccc(cc6C)-c7noc(C)n7)c4cc23

Gene Information

human ... HTR1B(3351)

Biochem/physiol Actions

Selective 5-HT1B serotonin receptor antagonist.

Legal Information

Sold under exclusive license from SmithKline Beecham Pharmaceuticals

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
P De Vries et al.
European journal of pharmacology, 362(1), 69-72 (1998-12-29)
In vagosympathectomised dogs pre-treated intravenously (i.v.) with mesulergine (300 microg/kg), 1-min intracarotid (i.c.) infusions of 5-hydroxytryptamine (5-HT; 0.3-30 microg/min) and sumatriptan (1-30 microg/min) dose-dependently decreased external carotid blood flow, without affecting mean blood pressure or heart rate. Treatment with the...
J V Selkirk et al.
British journal of pharmacology, 125(1), 202-208 (1998-10-17)
1. Human 5-HT1B (h5-HT1B) and human 5-HT1D (h5-HT1D) receptors show remarkably similar pharmacology with few compounds discriminating the receptors. We report here on a novel compound, SB-224289 (1'-Methyl-5-[[2'-methyl-4'-(5-methyl- 1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro spiro [furo [2,3-f]indole-3,4'-piperidine] oxalate), which has high affinity for h5-HT1B receptors...
L M Gaster et al.
Journal of medicinal chemistry, 41(8), 1218-1235 (1998-05-09)
5-HT1 receptors are members of the G-protein-coupled receptor superfamily and are negatively linked to adenylyl cyclase activity. The human 5-HT1B and 5-HT1D receptors (previously known as 5-HT1Dbeta and 5-HT1Dalpha, respectively), although encoded by two distinct genes, are structurally very similar....

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