Documents

S8942

Sigma-Aldrich

SB-216641

≥99% (HPLC), solid

Empirical Formula (Hill Notation):
C28H30N4O4 · HCl · 0.5H2O
Molecular Weight:
532.03
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

assay

≥99% (HPLC)

form

solid

color

white

solubility

DMSO: ~18 mg/mL at ≤60 °C
H2O: insoluble

storage temp.

−20°C

SMILES string

COc1ccc(NC(=O)c2ccc(cc2)-c3ccc(cc3C)-c4noc(C)n4)cc1OCCN(C)C

Gene Information

human ... HTR1B(3351), HTR1D(3352), HTR2A(3356)

Biochem/physiol Actions

5-HT1B serotonin receptor antagonist

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

WGK Germany

3

Certificate of Analysis
Certificate of Origin
S E Hopwood et al.
Neuropharmacology, 40(4), 508-519 (2001-03-16)
The present study investigated the possibility of multiple 5-HT(1) autoreceptor subtypes in the rostral raphé nuclei. Slices (350 microm) of rat dorsal or median raphé nucleus (DRN/MRN) were taken from male Wistar rats and superfused with artificial cerebrospinal fluid at...
G W Price et al.
Naunyn-Schmiedeberg's archives of pharmacology, 356(3), 312-320 (1997-09-26)
Despite only modest homology between h5-HT1B and h5-HT1D receptor amino acid sequences, these receptors display a remarkably similar pharmacology. To date there are few compounds which discriminate between these receptor subtypes and those with some degree of selectivity, such as...

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