SAB4502942

Sigma-Aldrich

Anti-TIE2, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):
hTIE2, p140 TEK, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 125 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

application(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100

conjugate

unconjugated

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TEK(7010)

General description

The TIE2 (TEK receptor tyrosine kinase) gene is mapped to human chromosome 9p21.2. It is predominantly expressed in the Schlemm′s canal endothelial of the eye.
Anti-TIE2 Antibody detects endogenous levels of total TIE2 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human TIE2.

Immunogen Range: 1068-1117

Biochem/physiol Actions

Tie-2 (TEK receptor tyrosine kinase) protein induces angiogenesis (both developmental and tumor) and supports endothelial cell survival, upon binding of angiopoietin-1 (an endothelial growth factor) to the receptor. Tie-2 is necessary for Schlemm′s canal formation. The gene regulates vascular homeostasis by involving in auto or transphosphorylation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma.
Kim J
The Journal of Clinical Investigation, 127(10), 3877-3896 (2017)
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.
Souma T
The Journal of Clinical Investigation, 126(7), 2575-2587 (2016)
Angiopoietin-2 and soluble Tie-2 receptor plasma levels in children with obstructive sleep apnea and obesity.
Gozal D
Obesity (Silver Spring, Md.), 25(6), 1083-1090 (2017)
Hisashi Takada et al.
Cancer science, 96(2), 100-110 (2005-02-23)
We performed genome-wide screening for deoxyribonucleic acid copy-number aberrations in 31 gastric cancer (GC) cell lines by using custom-made comparative genomic hybridization (CGH)-array. Copy-number gains were frequently detected at 1q, 3q, 5p, 7p, 7q, 8q, 11q, 17q, 20p, 20q, Xp...
Jaeryung Kim et al.
Science advances, 5(2), eaau6732-eaau6732 (2019-02-23)
Choriocapillary loss is a major cause of neovascular age-related macular degeneration (NV-AMD). Although vascular endothelial growth factor (VEGF) blockade for NV-AMD has shown beneficial outcomes, unmet medical needs for patients refractory or tachyphylactic to anti-VEGF therapy exist. In addition, the...

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