SAB4503999

Sigma-Aldrich

Anti-phospho-TIE2 (pTyr1108) antibody produced in rabbit

affinity isolated antibody

NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 125 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

application(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

conjugate

unconjugated

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TEK(7010)

General description

The TIE2 (TEK receptor tyrosine kinase) is also termed as TEK (tyrosine-protein kinase receptor). This gene is located on human chromosome 9p21.2. It is expressed in the Schlemm′s canal endothelial of the eye. TIE2 belongs to the receptor tyrosine kinases family.

Immunogen

The antiserum was produced against synthesized peptide derived from human TIE2 around the phosphorylation site of Tyr1108.

Immunogen Range: 1074-1123

Biochem/physiol Actions

Tie-2 (TEK receptor tyrosine kinase) protein induces angiogenesis and supports endothelial cell survival, upon binding of angiopoietin-1 (an endothelial growth factor) to the receptor. This gene is necessary for Schlemm′s canal formation. This gene regulates vascular homeostasis by involving in auto or transphosphorylation. Tie-2 is essential for the growth of vascular structures during embryogenesis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation
Hossain MB, et al.
Molecular and Cellular Biology (2017)
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
Davis S, et al.
Cell, 87(7), 1161-1169 (1996)
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
Suri C, et al.
Cell, 87(7), 1171-1180 (1996)
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.
Souma T
The Journal of Clinical Investigation, 126(7), 2575-2587 (2016)
Angiopoietin-2 and soluble Tie-2 receptor plasma levels in children with obstructive sleep apnea and obesity.
Gozal D
Obesity (Silver Spring, Md.), 25(6), 1083-1090 (2017)

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