T183

Sigma-Aldrich

TaiCatoxin from Oxyuranus s. scutellatus (Taipan snake) venom

>97%, lyophilized powder

Synonym(s):
TCX
CAS Number:
MDL number:

assay

>97%

form

lyophilized powder

storage temp.

−20°C

Biochem/physiol Actions

TaiCatoxin from Tiapan snake venom is a potent cardiac calcium channel blocker that has phospholipase A2 activity. This venom can induce the release Iysophospholipids and FFA (acyl CoA and acyl carnitine) which can disrupt cell integrity and function. Furthermore, taiCatoxin can block the calcium dependent movement of outer hair cells in mammals.
Selective and reversible blocker of voltage-dependent L-type Ca2+ channels in excitable membranes.

Certificate of Analysis

Certificate of Origin

H E Saqr et al.
Neurochemistry international, 35(6), 411-422 (1999-10-19)
PDGF-BB induces a rapid, sustained increase in intracellular calcium levels in U-1242 MG cells. We used several calcium channel blockers to identify the types of channels involved. L channel blockers (verapamil, nimodipine, nicardipine, nitrendipine and taicatoxin) had no effect on...
E Fantini et al.
Molecular and cellular biochemistry, 160-161, 61-66 (1996-07-01)
TaiCatoxin (TCX), a complex toxin isolated from Taipan snake venom, is believed to have a specific blocking activity on voltage-dependent cardiac calcium channels. The aim of this study was to investigate the effects of TCX on a broad range of...
L D Possani et al.
Toxicon : official journal of the International Society on Toxinology, 30(11), 1343-1364 (1992-11-01)
Taicatoxin is a new complex oligomeric toxin that was isolated from the venom of the Australian taipan snake Oxyuranus scutellatus scutellatus. It is composed of three different molecular entities: an alpha-neurotoxin-like peptide of mol. wt 8000, a neurotoxic phospholipase of...
K B Doorty et al.
The Journal of biological chemistry, 272(32), 19925-19930 (1997-08-08)
Taicatoxin, isolated from the venom of the Australian taipan snake Oxyuranus scutellatus, has been previously regarded as a specific blocker of high threshold Ca2+ channels in heart. Here we show that taicatoxin (in contrast to a range of other Ca2+...
Mao-Chang Su et al.
Hearing research, 203(1-2), 172-179 (2005-04-28)
The effects of taicatoxin on the slow motility of isolated outer hair cells of guinea pig were studied in the experiments. Pretreatment with taicatoxin (0.19 microM) was able to prevent both the cell shortening induced by high K(+) (50mM), and...

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