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T2379

Sigma-Aldrich

Tubocurarine hydrochloride pentahydrate

≥97%

Synonym(s):
(+)-Tubocurarine hydrochloride
Empirical Formula (Hill Notation):
C37H41ClN2O6 · HCl · 5H2O
CAS Number:
Molecular Weight:
771.72
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥97%

solubility

H2O: soluble 50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow
ethanol: soluble
methanol: soluble

storage temp.

2-8°C

SMILES string

O.O.O.O.O.Cl.[Cl-].COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4

InChI

1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1

InChI key

WMIZITXEJNQAQK-GGDSLZADSA-N

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Application

Tubocurarine hydrochloride pentahydrate has been used as a acetylcholinesterase inhibitor (Ach) inhibitor in myotubes, muscle and as neuromuscular junction blocker in zebra fish embryos.

Biochem/physiol Actions

Tubocurarine is a muscle relaxant and a nicotinic acetylcholine receptor antagonist. It can induce neuromuscular blocking.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Tubocurarine hydrochloride pentahydrate is soluble in water at 50 mg/ml (with heat as required) and yields a clear to slightly hazy, colorless to yellow solution. It is also soluble in methanol and ethanol.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More documents

Quotes and Ordering

Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis
Muto A, et al.
Proceedings of the National Academy of Sciences of the USA, 108(13), 5425-5425 (2011)
Matthew Lovett-Barron et al.
Nature neuroscience, 23(8), 959-967 (2020-06-24)
The hypothalamus is composed of many neuropeptidergic cell populations and directs multiple survival behaviors, including defensive responses to threats. However, the relationship between the peptidergic identity of neurons and their roles in behavior remains unclear. Here, we address this issue
A Ashkenazi et al.
Journal of the neurological sciences, 164(2), 124-128 (1999-07-13)
The pharmacology of auditory brain-stem evoked potentials (ABEP) pathways is poorly understood. There are anecdotal reports on the involvement of various neurotransmitters but they were not investigated systematically. The aim of this study was to investigate the effects on ABEP
Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis
Gomez A, et al.
Journal of immunology (Baltimore, Md. : 1950), 186(4), 2503-2513 (2011)
The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium
Wenningmann I and Dilger JP
Molecular Pharmacology, 60(4), 790-796 (2001)

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