T3397

Sigma-Aldrich

Tylosin solution

8 mg/mL in 0.9% NaCl, sterile-filtered, BioReagent, suitable for cell culture

CAS Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.76
Pricing and availability is not currently available.

Quality Level

sterility

sterile-filtered

product line

BioReagent

form

solution

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and keep upright to prevent leakage.)

concentration

8 mg/mL in 0.9% NaCl

application(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

colorless to yellow

Mode of action

protein synthesis | interferes

antibiotic activity spectrum

Gram-positive bacteria
mycoplasma

storage temp.

2-8°C

SMILES string

OC@H(C@@H(O)C(O)=O)C(O)=O.CCC@H1OC(=O)CC@@H(O)C@H(C)C@@H(OC@@H2OC@H(C)C@@H(OC@H3CC@@(C)(O)C@@H(O)C@H(C)O3)C@@H(C@H2O)N(C)C)C@@H(CC=O)CC@@H(C)C(=O)\C=C\C(C)=C\C@@H1COC@@H4OC@H(C)C@@H(O)C@@H(OC)C@H4OC

InChI

1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1

InChI key

ICVKYYINQHWDLM-KBEWXLTPSA-N

Related Categories

General description

Chemical structure: macrolide
Tylosin is a macrolide antibiotic, which comprises of a 16-member lactone ring. This solution is recommended for use at 1 mL/L.

Application

Tylosin solution has been used as an antimicrobial agent in antibiotic susceptibility minimal inhibitory concentration(MIC) of E. coli and S. aureus isolates. It has also been used as a component of Dulbecco′s modified Eagle′s (DMEM) medium for self-inactivating lentivirus production and skin fibroblast cultivation.

Biochem/physiol Actions

Tylosin inhibits bacterial protein synthesis by binding to the large subunit 50S. It is effective against Gram-positive bacteria and mycoplasma and is used in veterinary medicine. It has been used to study implant site abscess prevention in cattle and Mycoplasma gallisepticum and Mycoplasma meleagridis infections.

Packaging

20ML

Preparation Note

This product was formulated to contain 8 mg/ml tylosin in 0.9% sodium chloride.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Antibiotic susceptibility patterns of beta-lactamase-producing Escherichia coli and Staphylococcus aureus isolated from chickens in Maiduguri (Arid zone), Nigeria
A Mamza S, et al.
Veterinarski Archiv / Veterinary Archives, 80(2), 283-297 (2010)
Effects of a tylosin tartrate pellet added to cattle growth implants on the incidence of implant site abscesses
Zollers JrWG, et al.
The Protein Kinase Facts Book, 18(3), 258-261 (2002)
EVALUATION OF THE EFFECT OF TYLOSIN (MACROLIDE ANTIBIOTICS) ON MURINE TOXOPLASMOSIS
Asgari Q, et al.
International Journal of Pharmaceutical Sciences and Research, 9(7), 2891-2896 (2018)
Bei Liu et al.
Journal of hazardous materials, 325, 129-135 (2016-12-09)
In order to be more practical on evaluating the response of soil microbial communities to Cu contamination, we compared the microbial activity and selection for the microbial tolerance after a high level Cu exposure in single and corresponding repeated addition....
Tools for characterizing bacterial protein synthesis inhibitors
Orelle C, et al.
Antimicrobial Agents and Chemotherapy, 57(12), 5994-6004 (2013)

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