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T4193

Sigma-Aldrich

TNP-ATP hydrate

≥90% (HPLC), powder

Synonym(s):
2′,3′-O-(2,4,6-Trinitrophenyl) adenosine 5′-triphosphate monolithium trisodium salt
Empirical Formula (Hill Notation):
C16H13N8O19P3LiNa3 · xH2O
Molecular Weight:
790.15 (anhydrous basis)

assay

≥90% (HPLC)

form

powder

color

red to orange

solubility

H2O: <5 mg/mL
PBS: soluble

shipped in

dry ice

storage temp.

−70°C

SMILES string

[Li+].O.[Na+].[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)CP([O-])(=O)CP([O-])([O-])=O)[C@H]4OC5(O[C@@H]34)C(CC(CC5[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O

Application

TNP-ATP has been used to inhibit P2X4 in rat microglial cells2. It has also been used as a P2X receptor antagonist in mice3.

Biochem/physiol Actions

TNP-ATP hydrate is a purinoceptor P2X2/3 antagonist.

Preparation Note

TNP-ATP hydrate is soluble in water at a concentration that is less than or equal to 5 mg/ml. It is also soluble in PBS3.

Certificate of Analysis

Certificate of Origin

M F Jarvis et al.
British journal of pharmacology, 132(1), 259-269 (2001-01-13)
1. Exogenous ATP produces acute and localized pain in humans, and P2X receptor agonists elicit acute nociceptive behaviours in rodents following intradermal administration to the hindpaw. The predominant localization of P2X(3) mRNA in sensory neurones has led to the hypothesis
Koji Atarashi et al.
Nature, 455(7214), 808-812 (2008-08-22)
Interleukin (IL)-17-producing CD4(+) T lymphocytes (T(H)17 cells) constitute a subset of T-helper cells involved in host defence and several immune disorders. An intriguing feature of T(H)17 cells is their selective and constitutive presence in the intestinal lamina propria. Here we
Fan Li et al.
BMC neuroscience, 12, 111-111 (2011-11-08)
Activation of amoeboid microglial cells (AMC) and its related inflammatory response have been linked to the periventricular white matter damage after hypoxia in neonatal brain. Hypoxia increases free ATP in the brain and then induces various effects through ATP receptors.

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