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Tolmetin sodium salt dihydrate

1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium salt dihydrate
Linear Formula:
C15H14NO3Na · 2H2O
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:


H2O: soluble 50 mg/mL, clear, colorless

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An NSAID. Circumvents MRP-mediated multidrug resistance. Significantly increases the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine.

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Antonio Tito et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 72(5), 1000-1006 (2009-02-03)
The formation of tolmetin/N-acetyl-l-tyrosine ethyl ester (ATEE) complex has been reported by means of both theoretical and experimental studies, including quantum mechanical calculations as well as UV-vis absorption, fluorescence and time-resolved spectroscopy measurements. It has been found that the fluorescence
Kishore Kumar Hotha et al.
Biomedical chromatography : BMC, 24(10), 1100-1107 (2010-09-21)
A highly sensitive, rapid assay method has been developed and validated for the simultaneous estimation of tolmetin (TMT) and MED5 in human plasma with liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive-ion mode. A simple
Jessica H Kennedy et al.
Reproductive biology and endocrinology : RB&E, 1, 74-74 (2003-11-14)
Turkey reproduction is by artificial insemination using pooled semen so there is interest in storing semen. Fertilizing capacity declines after six hours storage, possibly due to poor sperm mobility. Prostaglandins (PG) affect mammalian sperm motility, but avian sperm has not
Embedded-polar-group bonded phases for high performance liquid chromatography.
O'Gara, J. E., et al.
LC-GC, 19(6), 632-642 (2001)
R Scott Obach
Drug metabolism and disposition: the biological fate of chemicals, 37(8), 1581-1586 (2009-05-15)
During an investigation of the in vitro glucuronidation of benoxaprofen by human liver S-9 fraction, an unusual drug-related entity possessing a protonated molecular ion that was 74 mass units greater than the parent drug was observed. It was identified as

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