T7313

Sigma-Aldrich

1-2-(Trifluoromethyl)phenylimidazole

Synonym(s):
TRIM
Empirical Formula (Hill Notation):
C10H7F3N2
CAS Number:
Molecular Weight:
212.17
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

biological source

synthetic (organic)

assay

≥98% (GC)

form

solid

solubility

DMSO: soluble 30 mg/mL

storage temp.

2-8°C

SMILES string

FC(F)(F)c1ccccc1-n2ccnc2

InChI

1S/C10H7F3N2/c11-10(12,13)8-3-1-2-4-9(8)15-6-5-14-7-15/h1-7H

InChI key

WZBWBNCQUTXYEL-UHFFFAOYSA-N

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

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Biochem/physiol Actions

Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-36

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Jose A Adams et al.
Resuscitation, 74(3), 516-525 (2007-05-01)
Nitric oxide (NO) is a critical regulator of vascular tone, and signal transduction. NO is produced via three unique synthases (NOS); endothelial (eNOS), and neuronal (nNOS) are both constitutively expressed and inducible (iNOS) produced primarily after stimulation. NO has been...
Dongmei Wu et al.
Resuscitation, 73(1), 144-153 (2007-02-24)
The purpose of the present study was to identify the roles of the three nitric oxide synthase (NOS) isoforms on whole body ischemia-reperfusion injury during cardiopulmonary resuscitation (CPR) with periodic acceleration (pGz) in pigs. Thirty-two anesthetized pigs (27.6+/-3.4 kg) were...
Juan Traba et al.
Scientific reports, 9(1), 9473-9473 (2019-07-03)
Farmland bird populations have strongly declined across Europe over the last decades due to agriculture intensification, despite successive reforms of EU's Common Agricultural Policy (CAP). In parallel, CAP has led to a reduction of fallow land, a critical habitat for...
Yves Basset et al.
Ecology and evolution, 7(23), 9991-10004 (2017-12-15)
We have little knowledge of the response of invertebrate assemblages to climate change in tropical ecosystems, and few studies have compiled long-term data on invertebrates from tropical rainforests. We provide an updated list of the 72 species of Saturniidae moths...
Vallo Volke et al.
Behavioural brain research, 140(1-2), 141-147 (2003-03-20)
Various inhibitors of nitric oxide synthase (NOS) have been shown to possess antidepressant- and anxiolytic-like properties in animal models. The aim of this study was to compare the behavioural effects of NOS inhibitor 7-nitroindazole (7-NI) with the more selective neuronal...

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