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V1008

Sigma-Aldrich

Val-Gly-Val-Ala-Pro-Gly

≥97% (HPLC)

Empirical Formula (Hill Notation):
C22H38N6O7
CAS Number:
Molecular Weight:
498.57
MDL number:
PubChem Substance ID:

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(C)C(N)C(=O)NCC(=O)NC(C(C)C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NCC(O)=O

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Biochem/physiol Actions

Recognition sequence for the elastin receptor. Acts on vascular smooth muscle cells to release matrix metalloproteinase 1 (collagenase) and may induce angiogenesis.
Chemotactic toward fibroblasts and monocytes.

Other Notes

Repeating peptide in elastin.

Certificate of Analysis

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Certificate of Origin

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More documents

Quotes and Ordering

H Wachi et al.
FEBS letters, 368(2), 215-219 (1995-07-17)
Synthetic elastin peptides, VPGVG or its polymer (VPGVG)n, enhanced the proliferation of smooth muscle cells 1.5-fold during 48 h treatment at the concentrations over 10(-6) M or 1.0 microgram/ml, respectively. Monomeric and polymeric VPGVG sequences reduced elastin synthesis and its
Iori Maeda et al.
Journal of biochemistry, 142(5), 627-631 (2007-10-24)
A polyclonal antibody to elastin-derived hexapeptide repeat, H-(Val-Gly-Val-Ala-Pro-Gly)(3)-NH(2), was prepared in order to investigate the differences between elastin fibres in intimal hyperplasia and media in human atheroscleroic lesions. The hexapeptide repeat and alpha-elastin were recognized by this polyclonal antibody in
C H Blood et al.
The Journal of cell biology, 107(5), 1987-1993 (1988-11-01)
Extracellular matrix proteins and their proteolytic products have been shown to modulate cell motility. We have found that certain tumor cells display a chemotactic response to degradation products of the matrix protein elastin, and to an elastin-derived peptide, VGVAPG. The
Elastin degradation products induce adventitial angiogenesis in the Anidjar/Dobrin rat aneurysm model.
G B Nackman et al.
Annals of the New York Academy of Sciences, 800, 260-262 (1996-11-18)
G B Nackman et al.
Surgery, 122(1), 39-44 (1997-07-01)
Infusion of the abdominal aorta with pancreatic elastase induces aneurysms in a rat model (Anidjar/Dobrin). Because elastolysis liberates elastin degradation products (EDPs), the present experiment was carried out to test the hypothesis that an EDP alone could induce features of

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