1400W dihydrochloride

>98%, solid

N-(3-(Aminomethyl)phenylmethyl)ethanimidamide dihydrochloride
Empirical Formula (Hill Notation):
C10H15N3 · 2 HCl
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.





storage condition




shipped in

wet ice

storage temp.


SMILES string




InChI key


Gene Information

human ... NOS1(4842), NOS2(4843), NOS3(4846)


1400W dihydrochloride has been used:
  • as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
  • as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
  • to study its efficacy on renal ischemia/ reperfusion injury in rats
  • as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation


10 mg in glass bottle

Biochem/physiol Actions

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion
Kesik V, et al.
The Journal of Surgical Research, 157(1), e97-e105 (2009)
L L Thomsen et al.
Cancer research, 57(15), 3300-3304 (1997-08-01)
We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is expressed in the...
E P Garvey et al.
The Journal of biological chemistry, 272(8), 4959-4963 (1997-02-21)
N-(3-(Aminomethyl)benzyl)acetamidine (1400W) was a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W showed saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constant of 2.0 microM....
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
Ersoz N, et al.
Renal Failure, 31(8), 704-710 (2009)
Sandy Santos-Pereira et al.
PloS one, 14(12), e0226837-e0226837 (2019-12-20)
Leishmaniasis encompass a group of infectious parasitic diseases occurring in 97 endemic countries where over one billion people live in areas at risk of infection. It is in the World Health Organization list of neglected diseases and it is considered...
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