Astec® CHIROBIOTIC® R Chiral HPLC Column

5 μm particle size, L × I.D. 25 cm × 4.6 mm

Pricing and availability is not currently available.


HPLC column

Quality Level


pkg of 1 ea

mfr. no.



0-45 °C temperature
241 bar pressure (3500 psi)


HPLC: suitable

L × I.D.

25 cm × 4.6 mm


high-purity silica gel particle platform

matrix active group

ristocetin A glycopeptide phase

particle size

5 μm

pore size

100 Å

operating pH range

3.5 - 6.8

separation technique


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General description

CHIROBIOTIC® R, based on the ristocetin A glycopeptide covalently bonded to high purity silica particles, has shown particular applicability to enantiomers of anionic compounds. Selectivity on CHIROBIOTIC® R strongly correlates to the organic modifier, favoring the alcohol-type mobile phases by a large margin.

  • Bonded phase: Ristocetin A
  • Operating pH range: 3.5 - 6.8
  • Particle diameter: 5, 10 or 16 μm
  • Pore size: 100 Å

CHIROBIOTIC Reference Bibliography
Chiral Product Literature

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Legal Information

Astec is a registered trademark of Sigma-Aldrich Co. LLC
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Certificate of Analysis
Certificate of Origin
B DeCruze et al.
Clinical oncology (Royal College of Radiologists (Great Britain)), 11(4), 252-254 (1999-09-04)
Poor prognosis (poorly differentiated and/or deep myometrial invasion) Stage I endometrial cancer can have a relapse rate as high as 50%. Traditionally, most clinical oncologists treat these patients with external beam radiotherapy after surgery but there is no evidence to...
Diane E Halliwell et al.
Scientific data, 4, 170084-170084 (2017-07-12)
Using a scanning near-field optical microscope coupled to an infrared free electron laser (SNOM-IR-FEL) in low-resolution transmission mode, we collected chemical data from whole cervical cells obtained from 5 pre-menopausal, non-pregnant women of reproductive age, and cytologically classified as normal...
Ting Zhou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1002, 218-227 (2015-09-06)
The chiral inversion has been a concerned issue during the research and development of a chiral drug. In this study, a sensitive chiral liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for determination of salbutamol enantiomers in human plasma and...
Sébastien Canneaux et al.
The journal of physical chemistry. A, 114(34), 9270-9288 (2010-08-03)
The rate constants of the reactions of iodine atoms with H(2), H(2)O, HI, and OH have been estimated using 39, 21, 13, and 39 different levels of theory, respectively, and have been compared to the available literature values over the...
P Dehouck et al.
Journal of chromatography. A, 1010(1), 63-74 (2003-09-25)
Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been developed. It makes use of an Astec C18 polymeric column. After validation in...
Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.
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Astec CHIROBIOTIC™ R Chiral HPLC Columns offered by our company. CHIROBIOTIC R is a new introduction into the series of HPLC phases utilizing macrocyclic glycopeptides as chiral selectors.
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